Many researchers in academia and industries are interested in reducing particle sizes from few submicrometers to nano-meter levels.These nano-particles find application in several areas including ceramics,paints,cosmetics,microelectronics,sensors,textiles and biomedical,etc.This article reviews the present state of the art for solid state synthesis of mineral nano-particles by wet milling,including their operating variables such as ball size,solid mass fraction and suspension stability.This article concludes and recommends with a critical discussion of nano-particles synthesis and a few common strategies to overcome stability issues. Many researchers in academia and industries are interested in reducing particle sizes from few submicrometers to nano-meter levels. The nano-particles find application in several areas including ceramics, paints, cosmetics, microelectronics, sensors, textiles and biomedical, etc. the present state of the art for solid state synthesis of mineral nano-particles by wet milling, including their operating variables such as ball size, solid mass fraction and suspension stability. this article concludes and recommends with a critical discussion of nano-particle synthesis and a few common strategies to overcome stability issues.