患者男,50岁,工人.患原发性高血压病8年,常服卡托普利、藻酸双酯钠,从未间断和更换其它药物.1997年3月6日因心慌、胸闷就诊,体检:心率120次/min,律齐,各瓣膜区未闻及杂音;血压18/12kPa;心电图示:窦性P波,P-R间期>0.12s,ST段下降,诊断为窦性心动过速而给予普萘洛尔(济南东风制药厂,批号950742)治疗,10mg,tid,po.用药至第2天下午7时许,病人觉双下肢膝关节以下发冷,小腿肌肉酸重感,脚部触之冰凉.病人自服感冒通2片,腓肠肌、足部经按摩、热敷治疗症状逐渐缓解.在以后的4天服药期间,均出现上述相同症状,晚间加重,经上述同样处理而缓解.同年4月18日,又因患窦性心动过速而给予普萘洛尔(批号同上)治疗,10mg,tid,po,服药至第二天下午6时许,又出现上述症状而复诊,考虑 Patient male, 50 years old, worker suffering from essential hypertension for 8 years, often taking captopril, sodium alginate, never discontinued and replaced by other drugs. March 6, 1997 due to palpitation, chest tightness, Physical examination: heart rate 120 beats / min, law Qi, the valve area is not heard and noise; blood pressure 18 / 12kPa; ECG shows: sinus P wave, PR interval> 0.12s, ST segment decreased diagnosis of sinus tachycardia While giving propranolol (Jinan Dongfeng Pharmaceutical Factory, batch number 950742) treatment, 10mg, tid, po. Drugs to the first 2 pm 7 pm, the patient felt lower extremity below the knee joint chills, calf muscle soreness, feet Department of cold touch.Patients self-serving flu through 2, gastrocnemius, foot massage, heat treatment symptoms gradually ease in the next 4 days during the medication, the above symptoms were the same, increased at night, by the same treatment and ease. April 18 the same year, but also due to suffering from sinus tachycardia and propranolol (lot number above) treatment, 10mg, tid, po, taking the next day at 6 pm, the recurrence of the above symptoms, consider