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目的探讨左卡尼汀对梗阻性无精症行再通术后精子活力的影响。方法选择深圳市蛇口人民医院2014年4月-2015年11月收治的82例梗阻性无精症患者为研究对象,以随机数字表法分为观察组和对照组各41例,所有患者均行再通术治疗,观察组在再通术治疗前服用左卡尼汀,对照组给予维生素E,对两组患者服药前后肿瘤坏死因子(TNF-α)、活性氧(ROS)水平及精子活力进行观察。结果治疗前两组患者TNF-α、ROS水平差异无统计学意义(P>0.05),观察组治疗后TNF-α、ROS水平明显低于对照组,两组差异有统计学意义(P<0.05);治疗前两组患者活动精子率、向前运动精子率差异无统计学意义(P>0.05),治疗后观察组活动精子率、向前运动精子率均高于对照组,差异有统计学意义(P<0.05)。结论左卡尼汀可通过调节梗阻性无精症患者TNF-α、ROS水平,从而提高精子活力,对改善患者预后具有重要意义,值得推广。
Objective To investigate the effect of levocarnitine on sperm motility after recanalization in patients with obstructive azoospermia. Methods Eighty-two patients with obstructive azoospermia who were treated in Shenzhen Shekou People’s Hospital from April 2014 to November 2015 were selected as the study subjects and divided into observation group and control group with 41 cases in random number table. All patients underwent The patients in the observation group were given L-carnitine before treatment of recanalization and the vitamin E in the control group. The levels of tumor necrosis factor (TNF-α), reactive oxygen species (ROS) and sperm motility Observed. Results There was no significant difference in TNF-α and ROS levels between the two groups before treatment (P> 0.05). The levels of TNF-α and ROS in the observation group were significantly lower than those in the control group ). There was no significant difference in sperm motility and motility sperm motility between the two groups before treatment (P> 0.05). After treatment, the sperm motility and forward sperm motility in the observation group were higher than those in the control group Significance (P <0.05). Conclusion L-carnitine can improve the sperm motility by regulating the level of TNF-α and ROS in patients with obstructive azoospermia, which is of great significance to improve the prognosis of patients.