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目的评价T-SPOT.TB在皮肤非结核分枝杆菌感染中的诊断价值。方法对3例拟诊为游泳池肉芽肿的患者在治疗前后进行T-SPOT.TB检测。结果例1显示相对分子质量6 000早期分泌靶向抗原(ESAT-6)阴性,相对分子质量10 000培养滤过蛋白肽段库(CEP-10)阳性;例2显示ESAT-6及CEP-10均阳性;例3显示ESAT-6阳性,CEP-10阴性。3例患者经过口服利福喷丁、乙胺丁醇和克拉霉素治疗4个月,皮损均获得痊愈。治疗后检测T-SPOT.TB,例1和例3阳性结果全部转阴。结论初步研究显示,在拟诊皮肤非结核分枝杆菌感染中检测T-SPOT.TB在快速和准确诊断方面有重要的参考意义。
Objective To evaluate the diagnostic value of T-SPOT.TB in skin non-tuberculosis infection. Methods T-SPOT.TB was detected in 3 patients diagnosed as swimming pool granuloma before and after treatment. Results Example 1 showed that the relative molecular mass of 6,000 was negative for early secretory target antigen (ESAT-6), and that the relative molecular mass of 10 000 culture filtrate peptide library (CEP-10) was positive. Example 2 shows that ESAT-6 and CEP- All positive; Example 3 shows ESAT-6 positive, CEP-10 negative. Three patients were treated with oral rifapentine, ethambutol and clarithromycin for 4 months, and all the lesions were cured. After treatment, T-SPOT.TB was detected. Positive results of cases 1 and 3 all turned negative. Conclusion Preliminary studies have shown that the detection of T-SPOT.TB in non-TB mycobacterial infections is an important reference for rapid and accurate diagnosis.