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近十年来,更注意于寻求治疗开角型青光眼的理想药物,需要的是一种能长期降低眼内压,同时不产生付作用的无毒药物。毛果芸香碱很有效,但引起瞳孔缩小和调节改变,患者有感不便;某些患者,尤其是年轻人近视和晶体中央部混浊者,较其他患者更为不便。肾上腺素是一种满意的无缩瞳作用药,已用于治疗青光眼多年,但其作用有限,单独使用时效果不够好。另外试用过儿茶酚胺。异丙肾上腺素有效,但即便局部用药也引起心动过速,终于放弃。羟甲异丁肾上腺素相当有效,但引起极度充血和不适,不能耐受。去甲肾上腺素作用不如肾上腺素强;肾上腺素仍是本组药物中最可取的药物。
In the past decade, more attention has been paid to the ideal drug for the treatment of open-angle glaucoma. What is needed is a non-toxic drug that can lower the intraocular pressure over a long period of time without producing any adverse effects. Pilocarpine is effective, but causes pupil constriction and changes in regulation, patients with inconvenience; some patients, especially young people with myopia and central opacity of the crystal, more inconvenient than other patients. Adrenaline is a satisfactory drug without miosis, has been used for many years in the treatment of glaucoma, but its effect is limited, the effect alone is not good enough. In addition tried catecholamines. Isoproterenol is effective, but even topical medication can cause tachycardia and finally give up. Methamphetamine is quite effective, but causes extreme congestion and discomfort, can not tolerate. Norepinephrine is not as strong as adrenaline; epinephrine is still the most desirable drug in this group.