脂质体载体经静注后,主要分布于富于网状内皮系的肝和脾,因而妨碍它进入其他靶组织。但对于网状内皮系方面的治疗,则能获得预期效果。例如包封五价锑剂葡萄糖酸锑钠(Pentostam)的脂质体,能显著提高对小鼠和仓鼠的实验性利什曼病的疗效。由于药物定向寄生虫感染的主要部位肝和脾,并且持续保持很高的药 After intravenous injection, the liposome carriers are mainly distributed in the liver and spleen rich in the reticuloendothelial system, thereby preventing it from entering other target tissues. But for the treatment of reticuloendothelial system, you can get the desired effect. For example, liposomes encapsulating Pentostam, a pentavalent antimony agent, can significantly improve the efficacy of experimental leishmaniasis in mice and hamsters. Due to drug-targeted parasites main parts of the liver and spleen infection, and continue to maintain a high drug