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目的:探讨恶性滋养细胞肿瘤化疗对女性生育机能影响及治疗与生育时间。方法:对我院1990年6月～2003年6月收住68例恶性滋养细胞肿瘤化疗患者进行回顾分析,并对34例要求生育患者进行了定期检查、随访。结果:68例除1例脑转移,转院治疗,1例阴道、肺转移死于栓塞外,其余全部治愈;治愈率达97.06%。通过对34例要求生育保留生育机能患者定期复查随访。1例在孕期,已有16例分娩,婴儿发育正常,母亲无复发,受孕分娩占要求生育患者的50.00%(17/34)。结论:化学治疗恶性滋养细胞肿瘤,保留生育机能是可行的,就诊时间迟早是保留生育机能的关键。治疗效果以发病时间在6个月以内为好,生育时间最好在治愈后避孕2年。
Objective: To investigate the influence of malignant trophoblastic tumor chemotherapy on female reproductive function and treatment and fertility time. Methods: 68 patients with malignant trophoblastic tumor and chemotherapy admitted to our hospital from June 1990 to June 2003 were retrospectively analyzed. 34 patients requiring fertility were examined regularly and followed up. Results: In 68 cases, except one case of brain metastasis and transfer of treatment, one case of vaginal and pulmonary metastasis died of embolization, and the rest were all cured. The cure rate was 97.06%. Through the 34 cases of reproductive function required to keep reproductive patients regular follow-up. One case in pregnancy, there have been 16 cases of childbirth, normal infant development, the mother without recurrence, fertilization accounted for 50.00% of reproductive births (17/34). Conclusion: It is feasible to treat malignant trophoblastic tumor with preserving reproductive function, and it is the key to keep the reproductive function in time. Treatment of onset time of less than 6 months as well, the best time of childbirth after the cure contraceptive 2 years.