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目的：评价急性心肌梗死患者中采取早期开通梗死相关动脉行溶栓治疗对血浆脑钠素(BNP)水平及左心功能的改善效果。方法选择我院92例急性心肌梗死患者，均为首次发病，且发病时间均在12h内，随机分为两组各46例，对照组未开通梗死相关动脉溶栓，观察组早期开通梗死相关动脉溶栓。全部在入院时和发病1周后对血浆BNP进行检测，并在1周后检查超声心动图，分析两组患者的左心重构及左心功能情况，并比较不良事件发生率。结果观察组1周后血浆BNP水平较观察组低(P <0.05)，且观察组左心功能各项指标情况较对照组改善更为明显(P <0.05)。观察组不良事件发生率显著低于对照组(P <0.05)。结论早期开通梗死相关动脉溶栓治疗急性心肌梗死能有效降低血浆BNP浓度，并对左室重构产生一定抑制作用，有效改善左心功能各项指标，从而降低了心脏不良事件的发生率。“,”Objective To evaluate the effect of early recanalization of the infarct related artery thrombolytic therapy on left ventricular function and BNP level in patients with acute myocardial infarction. Methods 92 patients with acute myocardial infarction were divided into control and observation group randomly, with 46 patients in each group, the onset time of all the patients were within 12h, and all were the first onset. Patients in control group were given conventional treatment, and patients in observation group were given early recanalization of the infarct related artery thrombolytic therapy. Plasma BNP level of all the patients were tested on admission and 1 week after onset, left ventricular remodeling and left ventricular function were recorded and analyzed by echocardiography,And carries on the comparison to the incidence of adverse events. Results Plasma BNP level in observation group were lower than in control group significantly(P <0.05). The left ventricular function situation in observation group was better than in control group significantly(P <0.05). Observation group, incidence of adverse events was significantly lower than the control group(P <0.05). Conclusion Early recanalization of the infarct related artery thrombolytic therapy reduced plasma BNP concentration and has a certain inhibitory action on the left ventricular remodeling, it improves left heart function situation effectively leading to low incidence of adverse cardiac events in patients with acute myocardial infarction.