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目的:观察中西医结合治疗小儿急性上呼吸道感染的临床疗效,及对患儿血清肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平的影响。方法:选取128例急性上呼吸道感染患儿,随机分为对照组和观察组,每组64例。对照组给予口服利巴韦林颗粒治疗,观察组在口服利巴韦林颗粒基础上加服小儿柴桂退热颗粒。比较2组临床疗效,及治疗前后炎症因子水平的变化,观察不良反应情况。结果:观察组愈显率84.37%,对照组愈显率68.75%,2组比较,差异有统计学意义(P<0.05)。观察组退热、咳嗽、鼻塞流涕及咽喉肿痛好转时间均短于对照组(P<0.05)。治疗后,2组TNF-α和IL-6水平均较治疗前下降(P<0.05);观察组的TNF-α和IL-6水平均较对照组下降更显著(P<0.05)。观察组患儿出现恶心呕吐2例,对照组患儿出现恶心呕吐3例,经及时停药或对症处理后均消失。结论:在口服利巴韦林颗粒的基础上加服小儿柴桂退热颗粒治疗小儿急性上呼吸道感染,可提高临床疗效,缩短病程。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of pediatric acute upper respiratory tract infection and its effect on serum levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in children. Methods: A total of 128 children with acute upper respiratory tract infection were selected and randomly divided into control group and observation group, with 64 cases in each group. The control group was treated with oral ribavirin granules. The observation group was given oral administration of ribavirin granules on the basis of oral administration of ribavirin granules. The clinical efficacy of the two groups were compared, and the changes of inflammatory cytokines before and after treatment were compared to observe the adverse reactions. Results: The cure rate of the observation group was 84.37%, while that of the control group was 68.75%. There was significant difference between the two groups (P <0.05). The observation group, fever, cough, nasal congestion and sore throat improved time were shorter than the control group (P <0.05). After treatment, the levels of TNF-α and IL-6 in two groups were significantly lower than those before treatment (P <0.05). The levels of TNF-α and IL-6 in the two groups were significantly lower than those in the control group (P <0.05). In the observation group, nausea and vomiting occurred in 2 cases and in the control group, nausea and vomiting in 3 cases were observed. All patients disappeared after being stopped or symptomatically treated. Conclusion: The oral administration of ribavirin granules plus pediatric Chai Gui Jue Jiao particles in children with acute upper respiratory tract infection can improve clinical efficacy and shorten the course of the disease.