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采用放射免疫法观察了IL-1β对人牙周膜纤维细胞(HPLF)产生前列腺素E2(PGE2)的影响,发现IL-1β具有诱导HPLF产生PGE2的作用,其诱导作用有显著的浓度效应和时间效应.该结果提示在尖周病、牙周病发病过程中,IL-1β可通过诱导HPLF产生PGE2而参与牙槽骨的骨吸收。
The effect of IL-1β on prostaglandin E2 (PGE2) production by human periodontal ligament fibroblasts (HPLF) was observed by radioimmunoassay. It was found that IL-1β had the effect of inducing PGE2 production by HPLF and its inducing effect was significant Time effect. The results suggest that in the periodontal disease, periodontal disease pathogenesis, IL-1β can induce HPLF produce PGE2 and participate in alveolar bone resorption.