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目的 探讨组织蛋白酶D(cathepsin D ,Cath D)与涎腺腺样囊性癌 (salivaryadenoidcysticcarcinoma ,SACC)预后的关系。方法 采用免疫组织化学链亲和素法分析 5 2例SACC的Cath D表达 ,并统计学分析Cath D与SACC病理学分型、临床分期、局部复发、远处转移和患者生存率的关系。结果 Cath D表达与SACC病理学分型、局部复发和患者生存率无明显相关 (P >0 0 5 ) ,而与临床分期和远处转移呈正相关关系 (P <0 0 5 )。结论 Cath D能通过溶解基底膜、细胞外间质和结缔组织 ,从而促进SACC的远处转移 ;Cath D可作为预后指标来预测SACC的远处转移 ,指导临床治疗
Objective To investigate the relationship between cathepsin D (Cath D) and the prognosis of salivary adenoid cystic carcinoma (SACC). Methods The expression of Cath D in 52 cases of SACC was analyzed by immunohistochemical streptavidin method, and the relationship between Cath D and SACC pathological type, clinical stage, local recurrence, distant metastasis and survival rate was statistically analyzed. Results There was no significant correlation between Cath D expression and SACC pathological type, local recurrence and survival (P 0 05), but positive correlation with clinical staging and distant metastasis (P <0 05). Conclusion Cath D can promote the distant metastasis of SACC by dissolving the basement membrane, extracellular matrix and connective tissue. Cath D can be used as a prognostic indicator to predict the distant metastasis of SACC and guide clinical treatment.