论文部分内容阅读
目的探讨发生在胸腔的混合性腺-神经内分泌癌的组织学特征和免疫表型。方法对3例发生在胸腔的混合性腺-神经内分泌癌的组织形态、组织化学染色、免疫组化染色及电镜进行观察,结合临床资料分析。结果癌组织由两种不同细胞成分构成,一种构成腺样、筛状结构,癌细胞呈柱状或印戒样,核染色质深;另一种构成实性巢团状、菊形团样结构,癌细胞呈小的卵圆形,胞质少,淡红染,核染色质细,肿瘤间质内血窦丰富。3例肿瘤细胞Syn和CK8/18(+),1例CgA(+),另1例CEA和CD56(+);但TTF-1均(-)。电镜下部分瘤细胞有少量神经分泌颗粒。结论胸腔混合性腺-神经内分泌癌是一种在组织形态和免疫表型上具有外分泌和内分泌肿瘤双重特点的肿瘤,诊断依靠组织学特征、免疫组化标记及电镜检查。肿瘤的生物学行为尚不确定。
Objective To investigate the histological features and immunophenotype of mixed glandular-neuroendocrine carcinoma in the thorax. Methods Three cases of mixed glandular-neuroendocrine carcinoma in the thorax were observed by histological staining, immunohistochemistry and electron microscopy. The clinical data were analyzed. Results The cancerous tissue consisted of two different cellular components, one of which constituted an adenoid, a sieve-like structure, the cancerous cells were columnar or signet-ring-like, and the chromatin of the nucleus was dark; the other constituted a solid nest- , Small oval cancer cells, less cytoplasm, pale red dye, fine nuclear chromatin, interstitial sinus blood rich. Three tumor cells Syn and CK8 / 18 (+), one case of CgA (+), the other case of CEA and CD56 (+); but TTF-1 were (-). Some tumor cells under electron microscopy have a small amount of neurosecretory granules. Conclusions Thoracic mixed glandular-neuroendocrine carcinoma is a kind of tumor characterized by both exocrine and endocrine neoplasms on histomorphology and immunophenotype. The diagnosis depends on histological features, immunohistochemical markers and electron microscopy. The biological behavior of the tumor is uncertain.