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[目的]探讨兰索拉唑联合氟哌噻吨美利曲辛治疗功能性消化不良患者的疗效。[方法]将功能性消化不良患者70例,随机分为治疗组(35例)与对照组(35例)。治疗组接受氟哌噻吨美利曲辛联合兰索拉唑或氟哌噻吨美利曲辛联合兰索拉唑、莫沙必利治疗,对照组接受兰索拉唑或兰索拉唑联合莫沙必利治疗,疗程均为4周。比较2组治疗前后Leeds消化不良问卷(LDQ)、综合医院焦虑和抑郁情绪量表(hospital anxiety and depression scale,HAD)评分。对照组中治疗无效的患者,在原有治疗基础上加用氟哌噻吨美利曲辛继续治疗4周,再次比较其LDQ、HAD评分。[结果]治疗4周后,治疗组与对照组患者LDQ、HAD评分均较治疗前降低(P<0.05),但治疗组减分幅度更加显著(P<0.05)。对照组中14例治疗无效患者,加用氟哌噻吨美利曲辛治疗后6例有效,且LDQ、HAD评分均有降低(P<0.05)。[结论]氟哌噻吨美利曲辛联合常规方案治疗功能性消化不良可以取得较好的疗效。
[Objective] To evaluate the efficacy of lansoprazole combined with flupentixol and melitracen in patients with functional dyspepsia. [Methods] 70 patients with functional dyspepsia were randomly divided into treatment group (35 cases) and control group (35 cases). The treatment group received flupenthixol and melitracen combined with lansoprazole or flupentixol and melitracen combined with lansoprazole and mosapride, and the control group received lansoprazole or lansoprazole Mosapride treatment, treatment are 4 weeks. The Leeds dyspepsia questionnaire (LDQ), hospital anxiety and depression scale (HAD) scores were compared between the two groups before and after treatment. Patients in the control group who were ineffective were treated with flupentixol and melitracen for 4 weeks on the basis of the original treatment, and their LDQ and HAD scores were compared again. [Results] The LDQ and HAD scores of the treatment group and the control group were lower than those before treatment (P <0.05) after 4 weeks of treatment, but the reduction scale of the treatment group was more significant (P <0.05). In the control group, 14 cases were ineffective, and 6 cases were treated with flupentixol and melitracen, and the LDQ and HAD scores decreased (P <0.05). [Conclusion] flupentixol and melitracen combined with routine regimen in treating functional dyspepsia can achieve better curative effect.