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目的:对四逆汤传统汤剂、经方颗粒剂及单味配方颗粒剂中甘草苷的含量进行比较。方法:采用高效液相色谱法,Diamonsil C18色谱柱(4.6 mm×150 mm,5μm),流动相乙腈-0.5%冰乙酸(20∶80),流速0.7 mL.min-1,检测波长276 nm,柱温25℃,测定3种剂型中甘草苷的含量。结果:甘草苷(每处方)在传统汤剂中含量为31.13 mg,经方颗粒剂中含量为48.48mg,单味配方颗粒剂中含量为31.95。结论:3种剂型中指标性成分甘草苷的含量有显著性差异。可为四逆汤剂型的进一步研究提供科学依据。
Objective: To compare the contents of liquiritin in Sini decoction traditional decoction, Jing Fang granule and single prescription granule. Methods: Diamonsil C18 column (4.6 mm × 150 mm, 5 μm) was used in this study. The mobile phase was acetonitrile-0.5% glacial acetic acid (20:80) at a flow rate of 0.7 mL · min- The column temperature was 25 ℃, and the content of liquiritin in three dosage forms was determined. Results: The content of liquiritin (each prescription) was 31.13 mg in traditional decoction, 48.48 mg in Jingfang Granule, and 31.95 in single prescription granule. Conclusion: There are significant differences among the three dosage forms of liquiritin. For Sini Decoction dosage form for further research to provide a scientific basis.