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炎症性肠病(IBD)是一类病因不明的肠道慢性非特异性炎症性疾病。白藜芦醇(RSV)是一种提取自红葡萄酒的天然多酚类化合物,其为NAD+依赖的组蛋白去乙酰化酶SIRT1激动剂,具有抗氧化、抗炎、抗肿瘤、抗纤维化等多种生物学活性。RSV在IBD中的作用主要包括抗炎和抗纤维化两个方面,本文就其在IBD中的研究进展作一综述。
Inflammatory bowel disease (IBD) is a group of chronic non-specific inflammatory bowel disease of unknown etiology. Resveratrol (RSV) is a natural polyphenolic compound extracted from red wine, which is an NAD + -dependent histone deacetylase SIRT1 agonist with anti-oxidation, anti-inflammatory, anti-tumor and anti-fibrosis effects A variety of biological activity. The role of RSV in IBD mainly includes two aspects of anti-inflammation and anti-fibrosis. This article reviews the research progress in IBD.