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瘦素(1eptin,Lep)一直以来被认为是抑制肥胖症的主要物质,是ob基因的表达产物。Ob基因1994年由zhang等人使用定位克隆技术发现,在小鼠中该基因定位于6号染色体,而在人类细胞中则分布于7号染色体上,这两种不同种属的基因编码同一种蛋白质,显示了在物种之间具有极高的同源性。Ob~-/ob~-突变小鼠在个体发育早期即出现肥胖,进食过量,低温,高胰岛素血症,高血糖及其它代谢和神经内分泌异常等病症。在人类,ob基因突变也能够造成病态肥
Leptin (leptin, Lep) has long been considered the main substance that inhibits obesity, is the expression of the ob gene. The Ob gene was discovered by zhang et al. In 1994 using positional cloning techniques in which the gene is located on chromosome 6 in mice and on chromosome 7 in human cells, and the two different genera encode the same Proteins, showing very high homology among species. Ob ~ - / ob ~ - mutant mice appear in the early development of individuals obesity, excessive eating, hypothermia, hyperinsulinemia, hyperglycemia and other metabolic and neuroendocrine disorders and other diseases. In humans, ob gene mutations can also cause morbid fertilizer