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目的探讨影响结肠癌患者预后的影响因素,为临床治疗提供依据。方法选择性别、年龄、肿瘤大小、肿瘤部位、大体分型、分化程度、浸润深度、淋巴结转移、远处转移、癌胚抗原(CEA)、化疗、Dukes分期共计12项临床病理指标,用单因素和多因素分析的方法研究其对152例结直肠癌患者预后的影响。结果单因素分析提示:肿瘤大体类型、分化程度、浸润深度、淋巴结转移、远处转移、CEA指数和Dukes分期均为影响预后的因素(P均<0.01),而性别、年龄、肿瘤的大小、肿瘤部位、化疗则未显示对预后有影响(P>0.05);多因素分析提示:分化程度、淋巴结转移、CEA指数(P均<0.05)和大体类型(P<0.01)均为预后的独立影响因素,在这些独立影响因素中大体类型与预后的关系最为密切。结论分化程度、淋巴结转移、CEA指数和大体类型均为预后的独立影响因素。
Objective To investigate the influencing factors of prognosis in patients with colon cancer and provide basis for clinical treatment. Methods A total of 12 clinical and pathological parameters including gender, age, tumor size, tumor location, general classification, degree of differentiation, depth of invasion, lymph node metastasis, distant metastasis, carcinoembryonic antigen (CEA) And multivariate analysis of the 152 patients with colorectal cancer prognosis. Results Univariate analysis indicated that the general type of tumor, differentiation degree, depth of invasion, lymph node metastasis, distant metastasis, CEA index and Dukes stage were the prognostic factors (all P <0.01), but the gender, age, tumor size, Multivariate analysis showed that the degree of differentiation, lymph node metastasis, CEA index (all P <0.05) and general type (P <0.01) were independent prognostic factors Factors, among these independent factors, the general type and prognosis are the most closely related. Conclusion The degree of differentiation, lymph node metastasis, CEA index and gross type are independent prognostic factors.