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γ-氨基丁酸(γ-aminobutyric acid,GABA)是脑内抑制性通路的重要递质,并参与条件反射、睡眠和觉醒等生理机制。近年人们感兴趣的发现,在丘脑下部网状结构存在一个GABA能系统,对内分泌功能尤其对腺垂体激素分泌功能,有重要的调节作用。关于GABA对腺垂体黄体生成素(LH)分泌的影响,已有一些报导。Vijayan实验指出,将麻醉的雄性大鼠或预先将卵巢切除或预先将卵巢切除再给予雌、孕激素处理的清醒大鼠,由第三脑室注射(IVT)大剂量的GABA,皆能使血浆中
Gamma-aminobutyric acid (GABA) is an important transmitter of the inhibitory pathway in the brain and participates in physiological mechanisms such as conditional reflex, sleep and wakefulness. In recent years, people have been interested in the discovery that there is a GABAergic system in the hypothalamus reticular formation, which plays an important role in the regulation of endocrine function, especially the function of adenohypophysial hormone secretion. There have been some reports on the effect of GABA on the secretion of adenohypophysial luteinizing hormone (LH). Vijayan’s experiments indicate that anesthetized male rats or consciously treated ovaries or ovaries in advance to give estrogen or progesterone treatment to awake rats, and the third intraventricular injection (IVT) of a large dose of GABA can make the plasma