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目的 探讨符合线路SPECT 18F FDG显像在乳腺癌诊断及分期中的临床应用价值。方法 经组织学确诊的乳腺癌患者共 17例 ,术前及术后行18F FDG显像检查的患者分别为 9例和 8例。检查前患者禁食 6h以上 ,静脉注射18F FDG111～ 15 9.1MBq 1h后进行显像。图像经迭代法重建 ,并计算病灶与对侧相应部位或邻近正常组织的放射性计数比值 (T/B)。结果 乳腺原发恶性病灶 11个 ,18F FDG显像均可见局限性放射性异常浓聚 ,T/B值为 1.3 5～ 4.5 2 ;腋窝淋巴结转移灶 19个 ,18F FDG显像发现其中 5个有18F FDG摄取增高 ,T/B值为 1.3 7～ 2 .0 6。 5例18F FDG显像发现远处转移灶 ,2例患者18F FDG检查未见明显异常 ,结果与骨显像、超声、CT及MRI一致。 2个良性病灶CT和超声考虑为转移灶 ,而18F FDG显像未见FDG摄取增加。结论 符合线路SPECT18F FDG显像在乳腺癌诊断及分期方面有较好的临床应用价值 ,对肿物定性诊断优于CT和超声检查 ,但对腋窝淋巴结转移灶的检出率较低。
Objective To investigate the clinical value of line SPECT 18F FDG imaging in the diagnosis and staging of breast cancer. Methods A total of 17 patients with histologically diagnosed breast cancer were enrolled. Nine patients and eight patients underwent 18F FDG imaging before and after surgery. Before the test, the patients were fasted for more than 6h, and the images were taken after intravenous injection of 18F FDG 111 ~ 15 9.1MBq for 1h. The images were reconstructed by iterative method, and the radioactive count (T / B) ratio of the lesion to the corresponding contralateral side or adjacent normal tissues was calculated. Results In all 11 breast malignant lesions, localized abnormalities of radioactivity were found in 18F FDG imaging. The T / B values ranged from 1.3 5 to 4.5 2. There were 19 axillary lymph node metastases and 18F FDG imaging showed that 18F FDG uptake increased, T / B value of 1.3 7 ~ 2. Five cases of distant metastases were detected by 18F FDG imaging. No significant abnormalities were found in 18F FDG in 2 patients. The results were consistent with those of bone imaging, ultrasound, CT and MRI. Two benign lesions CT and ultrasound considered as metastases, while 18F FDG imaging showed no increase in FDG uptake. Conclusions Line SPECT 18F FDG imaging has good clinical value in the diagnosis and staging of breast cancer. The qualitative diagnosis of the tumor is superior to CT and ultrasonography, but the detection rate of axillary lymph node metastasis is low.