【摘 要】
：
A serials of novel 5-substituted benzyl-2,4-diamino pyrimidine derivatives have been synthesized and evaluated as inhibitors of c-Fms kinase by the standard MTT
【机 构】
：
School of Pharmaceutical Sciences,Laboratory of Computer-Aided Drug Design & Discovery
【基金项目】
：
the National High-Tech Research and Development Program of China(863Program);国家自然科学基金
论文部分内容阅读
A serials of novel 5-substituted benzyl-2,4-diamino pyrimidine derivatives have been synthesized and evaluated as inhibitors of c-Fms kinase by the standard MTT method.The results showed that compound 15,5-[3-methoxy-4-(pyridine-3-y1)benzy1]-2,4-diamino pyrimidine,had an IC50 of 1.45 μmol/L in inhibiting the proliferation of M-CSF-dependent myeloid leukemia cells in mice(NFS-60),which was similar with GW2580,a selective inhibitor of c-Fms kinase.
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