论文部分内容阅读
[目的]从免疫学和流行病学两个方面评价上海市虹口区6~14岁学龄儿童麻疹疫苗强化免疫的效果。[方法]强化免疫1个月后采集静脉血,采用ELISA法测定麻疹IgG抗体,与未参加强化免疫者的抗体水平进行比较。同时,收集研究个体的麻疹免疫史、麻疹病史、麻疹密切接触史等流行病学资料。[结果]不能认为强化免疫对提高虹口区6~14岁学龄儿童麻疹抗体的阳性率、保护率及几何抗体平均浓度有影响,麻疹疫苗接种2剂次与接种3~4剂次相比,抗体水平差异无统计学意义。[结论]强化免疫的目的是消除免疫空白,在常规免疫高接种率的地区,实施大规模的强化免疫是对疫苗资源、人力资源和财力资源的浪费,而查漏补种是经济有效的预防措施。
[Objective] To evaluate the effect of booster immunization of measles vaccine in school-age children aged 6-14 in Hongkou District of Shanghai from two aspects of immunology and epidemiology. [Method] Venous blood was collected one month after booster immunization. The measles IgG antibody was measured by ELISA and the antibody level of those who did not participate in booster immunization were compared. In the meantime, epidemiological data on measles immunization, history of measles and history of close contact with measles were collected. [Results] It is not considered that enhanced immunization can improve the positive rate of measles antibody, the protection rate and the average geometric antibody concentration of school-age children aged 6-14 in Hongkou District. Compared with the 3 to 4 doses of measles vaccine, No significant difference between the levels. [Conclusion] The purpose of intensive immunization is to eliminate the immune blanket. In the area of high immunization rate of routine immunization, large-scale intensive immunization is a waste of vaccine resources, human resources and financial resources, and leak detection replanting is a cost-effective prevention Measures.