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中国科学院上海药物研究所从云南出产的防己科植物地不容(Stephania epjgeae H.S.Lo)分离出轮环藤宁(Cycleanine),经溴甲烷制成二甲溴化轮环藤宁(CycleanineDimethobromide),简称环轮宁。环轮宁的结构与简箭毒碱相似,动物试验证明有降压作用和肌松作用。有关环轮宁的降压作用作者等已作报导,并成为临床上满意的控制性降压药。本文报导环轮宁肌松作用的试验结果。方法和结果本文所用溴化环轮宁(少部分实验曾用碘化环轮宁)由上海药物研究所供给
Chinese Academy of Sciences, Shanghai Institute of Materia Medica from Yunnan production of anti-Pinaceae can not step (Stephania epjgeae HSLo) isolated cycle ring Ning (Cycleanine), brominated methyl bromide bromine ring made of Cyclobalanol (CycleanineDimethobromide), referred to as the ring rather. The structure of Ringside is similar to that of Deltozschichlin, animal experiments have shown that antihypertensive effect and muscle relaxant effect. The authors of the antihypertensive effect of cromolyn have been reported and become clinically satisfactory as controlled antihypertensive drugs. This article reports the results of the trial of cyclosporin. Methods and Results Brominated cycloalixin used in this paper (a small amount of experimental use of cyclodextrin iodine) by the Shanghai Institute of Materia Medica