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自身免疫性疾病的发病机制主要在于机体自身耐受的破坏,机体产生自身抗体和(或)自身反应性淋巴细胞,导致疾病的发生。最近很多研究表明,吲哚胺2,3-二加氧酶(indoleamine 2,3-dioxyge-nase,IDO)催化的色氨酸代谢与自身免疫耐受机制有关,表达 IDO 的细胞能够抑制 T 细胞免疫应答,在自身免疫性疾病的发病机制中起重要作用。因而研究 IDO 介导色氨酸代谢途径可以为阐明自身免疫疾病的发病机制和治疗自身免疫性疾病提供一种全新的观念。
The pathogenesis of autoimmune diseases is mainly the destruction of the body’s own tolerance, the body produces autoantibodies and (or) reactive lymphocytes, leading to the occurrence of the disease. Recently, many studies have shown that the tryptophan metabolism induced by indoleamine 2,3-dioxygenase (IDO) is related to the mechanism of autoimmune tolerance. Cells expressing IDO can inhibit T cells Immune response plays an important role in the pathogenesis of autoimmune diseases. Thus, IDO-mediated tryptophan metabolism can provide a new idea for elucidating the pathogenesis of autoimmune diseases and treating autoimmune diseases.