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目的了解HIV/AIDS病人的生存情况和影响因素。方法应用回顾性队列研究法,收集南平市2009—2014年392例HIV/AIDS病人人口学、随访、治疗和死亡信息,用寿命表法和Kaplan-Meier法进行生存分析,用Cox比例风险模型进行单因素和多因素回归分析。结果 392例HIV/AIDS病人第1、2、3、4和5年的累计生存率分别为0.86、0.85、0.84、0.81和0.81。Cox比例风险回归模型分析发现,基线CD+4T淋巴细胞计数>200个/mm3、接受抗病毒治疗者风险较低,确诊时年龄越大死亡风险越高。结论尽早发现HIV感染、定期检测CD+4T淋巴细胞、及时进行抗病毒治疗,有利于延长病人生存时间。
Objective To understand the survival and influencing factors of HIV / AIDS patients. Methods A retrospective cohort study was conducted to collect demographic, follow-up, treatment and death information from 392 HIV / AIDS patients in Nanping from 2009 to 2014. Survival analysis was performed by life table method and Kaplan-Meier method, and Cox proportional hazards model Univariate and multivariate regression analysis. Results The cumulative survival rates at 1, 2, 3, 4 and 5 years in 392 HIV / AIDS patients were 0.86, 0.85, 0.84, 0.81 and 0.81, respectively. Cox proportional hazards regression model analysis found that baseline CD + 4T lymphocyte count> 200 / mm3, the risk of receiving antiretroviral therapy is low, the higher the age of diagnosis, the higher the risk of death. Conclusion Early detection of HIV infection, periodic detection of CD + 4T lymphocytes, and timely antiviral therapy are beneficial to prolong the survival time of patients.