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目的探讨亚甲基四氢叶酸还原酶(MTHFR)基因多态性与中国成人急性淋巴细胞白血病(ALL)易感性的关系。方法全面检索、收集研究MTHFR基因多态性与成人ALL关系的文献,对文献进行评价筛选,应用RevMan 5.1软件对纳入文献进行异质性检验和效应指标OR合并。结果共纳入3篇文献,包括ALL患者303例,对照629例。荟萃分析结果示:MTHFR基因677TT、CT的合并OR及95%CI分别为0.66(0.27,1.58),1.17(0.65,2.09);MTHFR基因1298 CC、AC的合并OR及95%CI分别为1.33(0.59,3.03),0.91(0.67,1.23)。结论 MTHFR基因C677T、A1298C多态性与成人ALL易感性无显著相关性。
Objective To investigate the relationship between methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and susceptibility to adult acute lymphoblastic leukemia (ALL) in China. Methods A comprehensive search and collection of literature about the relationship between MTHFR gene polymorphism and adult ALL was conducted. The literature was screened and evaluated. RevMan 5.1 software was used to examine the heterogeneity of included articles and the OR of ORs. Results A total of 3 articles were included, including 303 ALL patients and 629 controls. The meta-analysis results showed that the combined OR and 95% CI of MTHFR gene 677TT and CT were 0.66 (0.27,1.58) and 1.17 (0.65, 2.09), respectively. The combined OR and 95% CI of MTHFR gene 1298 CC and AC were 1.33 0.59, 3.03), 0.91 (0.67, 1.23). Conclusion MTHFR gene C677T, A1298C polymorphism and adult ALL susceptibility was not significantly correlated.