论文部分内容阅读
人类血小板特异性抗原(HPA)是表达于不同血小板膜糖蛋白(GP)上的抗原表位,是血小板外膜上特有的抗原决定簇。HPA的种族差异性可导致血小板同种免疫性疾病发生。特发性血小板减少性紫癜(ITP)是一种相当普遍的出血性疾病,目前认为其发病机制与同种免疫反应有关。本文介绍了HPA的命名、定位、分子学生物特征,与之相关的血小板膜糖蛋白,综述了国内外HPA基因多态性与ITP发病相关性研究。
Human platelet-specific antigen (HPA) is an epitope expressed on different platelet membrane glycoproteins (GPs) and is a unique antigenic determinant on the platelet outer membrane. Racial differences in HPA can lead to platelet alloimmune disease. Idiopathic thrombocytopenic purpura (ITP) is a fairly common hemorrhagic disease, and its pathogenesis is currently believed to be associated with an alloimmune response. This paper introduces the naming, localization, molecular biological characteristics of HPA, and its related platelet membrane glycoprotein, and reviews the correlation between HPA gene polymorphism at home and abroad and the incidence of ITP.