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目的探讨急性心肌梗死患者血清同型半胱氨酸(homocysteine,Hcy)水平变化及临床意义。方法选取2014年1月—2015年1月于建德市第一人民医院诊疗的急性心肌梗死患者84例作为观察组研究对象,同时选取自愿参加该项目调查的健康人84例作为对照组,检测2组研究对象刚入院时和心肌梗死治疗1个月后的血清同型半胱氨酸水平,并对血清同型半胱氨酸水平变化进行分析比较。结果刚入院时,观察组血清同型半胱氨酸水平为(38.8±10.2)μmol/L,正常对照组血清同型半胱氨酸水平为(7.4±3.5)μmol/L,观察组患者的血清同型半胱氨酸水平明显高于对照组(t=9.259,P<0.001)。治疗1个月后观察组患者的血清同型半胱氨酸水平为(17.1±5.4)μmol/L,与治疗前比较差异有统计学意义(t=6.063,P<0.001)。观察组患者治疗1个月后其血清同型半胱氨酸水平仍明显高于正常对照组健康人,2组比较差异有统计学意义(t=5.146,P<0.001)。结论血清同型半胱氨酸水平与急性心肌梗死关系密切,高血清同型半胱氨酸水平是急性心肌梗死的危险因素之一,检查血清同型半胱氨酸水平对心肌梗死的诊断有一定的临床意义。
Objective To investigate the changes of serum homocysteine (Hcy) level in patients with acute myocardial infarction and its clinical significance. Methods 84 patients with acute myocardial infarction diagnosed and treated in the First People’s Hospital of Jiande from January 2014 to January 2015 were selected as the observation group and 84 healthy volunteers who volunteered to participate in the project were selected as the control group. Serum homocysteine levels in the two groups immediately after admission to hospital and after 1 month of myocardial infarction were analyzed, and the changes of serum homocysteine levels were analyzed and compared. Results At the time of admission, the level of homocysteine in the observation group was (38.8 ± 10.2) μmol / L, the level of homocysteine in the control group was (7.4 ± 3.5) μmol / L, Cysteine levels were significantly higher than the control group (t = 9.259, P <0.001). The level of plasma homocysteine in the observation group was (17.1 ± 5.4) μmol / L after 1 month of treatment, with statistical significance (t = 6.063, P <0.001). The level of plasma homocysteine in the observation group was still significantly higher than that in the normal control group after 1 month of treatment. The difference between the two groups was statistically significant (t = 5.146, P <0.001). Conclusions The level of serum homocysteine is closely related to acute myocardial infarction. High serum homocysteine level is one of the risk factors for acute myocardial infarction. Serum homocysteine level has some clinical significance in the diagnosis of myocardial infarction significance.