以α-三唑基频那酮为起始原料,经缩合、环化和酰胺化反应合成了15个未见文献报道的化合物,其结构均经核磁共振氢谱、红外光谱和质谱确认。初步抑菌活性测试结果表明,在50 mg/L下,目标化合物对供试植物病原菌均有不同程度的抑制作用,其中化合物3a-3、3a-4、3a-5、3b-2和3b-3对番茄灰霉病菌Botrytis cinerea的抑制率达80%以上,3a-4和3a-5对棉花枯萎病菌Fusarium oxysporum vasinfectum的抑制率分别达78.6%和82.4%。 Fifteen unreported compounds were synthesized by condensation, cyclization and amidation reaction using α-triazolyl pinacolone as starting materials. Their structures were confirmed by 1H NMR, IR and MS. The results of the preliminary antibacterial activity test showed that the target compounds inhibited the tested plant pathogens to varying degrees under the concentration of 50 mg / L. Compounds 3a-3, 3a-4, 3a-5, 3b- 3 inhibited Botrytis cinerea to more than 80%. The inhibitory rates of 3a-4 and 3a-5 to Fusarium oxysporum vasinfectum were 78.6% and 82.4%, respectively.