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激素替代治疗(HRT)是指单用雌激素或雌孕激素联合使用治疗围绝经期症状以及由于缺乏雌激素导致的各种疾病。HRT可以缓解绝经期症状、降低绝经期女性死亡率、减少心血管疾病、预防骨质疏松引起的骨折以及减少痴呆,但是目前对于HRT仍然存在争议。关于激素使用时机、使用剂量、使用途径及选用激素进行短期或长期替代治疗时需要认真权衡风险与获益比,进行个体化治疗。
Hormone replacement therapy (HRT) refers to the combined use of estrogen or estrogen and progesterone treatment of perimenopausal symptoms and due to the lack of estrogen caused by various diseases. HRT can alleviate menopausal symptoms, reduce menopausal female mortality, reduce cardiovascular disease, prevent fractures caused by osteoporosis and reduce dementia, but HRT is still controversial. On the timing of the use of hormones, the use of dose, use and use of hormones for short-term or long-term replacement therapy need to carefully weigh the risk and benefit ratio, individualized treatment.