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目的分析孕中晚期产妇应用脐带血穿刺手术诊断的临床安全性及有效性。方法选取本院于2010年1月至2012年12月收治287例经血清筛查确认为唐氏综合征高风险产妇为研究对象,产妇经超声引导下行脐带血管穿刺手术,并对脐带血染色体进行分析。结果 287例产妇共检出染色体核型异常患者18例,异常率为(6.27%),其中21三体染色体异常有10例,占(3.48%),共有8例患者18号染色体异常,占(2.79%)。穿刺过程中共有42例(14.63%)胎盘穿刺渗血,脐带穿刺出血共有121例(42.16%),胎儿出现短暂心跳缓慢有5例(1.74%)。结论产前对产妇进行唐氏综合征筛查能有效提高胎儿染色体异常发生率,经超声引导下进行脐带血穿刺手术能有效提高诊断的安全性及有效性。
Objective To analyze the clinical safety and efficacy of umbilical cord blood puncture in the second trimester of pregnancy. Methods The hospital from January 2010 to December 2012 were treated in 287 cases of serum screening confirmed as Down’s syndrome risk maternal as the research object, maternal ultrasound guided downward umbilical cord blood vessel puncture, and the cord blood chromosomes analysis. Results A total of 287 maternal chromosomes were detected in 18 patients with abnormal karyotype, the rate of abnormality was (6.27%). Twenty-one of the 21 trisomy 21 cases accounted for 3.48% 2.79%). During the puncture, 42 cases (14.63%) had placental puncture and bleeding, 121 cases (42.16%) had umbilical cord puncture bleeding, and 5 cases (1.74%) had short-term fetal heartbeat slowly. Conclusion Prenatal maternal screening for Down Syndrome can effectively improve the incidence of fetal chromosomal abnormalities. Ultrasound-guided cord blood puncture surgery can effectively improve the safety and effectiveness of diagnosis.