支原体是引起宫内临床和亚临床感染,导致早产和不良妊娠结局的主要病原体之一。妊娠中晚期宫内支原体感染,使宫内环境发生改变,干扰母胎环境,导致早产和不良妊娠结局。本文就该期宫内支原体感染动物模型的建立,及其对宫内细胞因子、生物活性物质和免疫细胞影响的研究进展综述如 Mycoplasma is caused by intrauterine clinical and subclinical infection, leading to one of the major pathogens of premature delivery and adverse pregnancy outcomes. Mycoplasma intrauterine infection in late pregnancy, so that changes in intrauterine environment, interfere with the mother’s fetal environment, leading to premature delivery and adverse pregnancy outcomes. This article on the establishment of intrauterine mycoplasma infection in animal models, and its impact on intrauterine cytokines, bioactive substances and immune cells