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卵母细胞的成熟包括第一次减数分裂恢复、第一次减数分裂向第二次减数分裂转变、第二次减数分裂中期阻滞等过程,其中第一次减数分裂向第二次减数分裂的转变是卵母细胞成熟的关键步骤之一,但其机制目前尚不清楚。丝裂原激活蛋白激酶、成熟促进因子、内源性减数分裂抑制因子、Separase/Securin蛋白、Aurora激酶等多种已知或未知的蛋白可通过泛素-蛋白酶体通路、磷脂酰肌醇通路、受体酪氨酸激酶-Ras蛋白通路、环磷酸腺苷通路等多个信号通路调控卵母细胞的成熟。通过研究这些通路中关键蛋白间的相互作用有助于进一步探索卵母细胞成熟的调控机制。
Oocyte maturation includes the first meiosis recovery, the first meiosis to the second meiotic change, the second metaphase arrest and so on, of which the first meiosis to the The transformation of the second meiosis is one of the key steps of oocyte maturation, but the mechanism is not yet clear. A variety of known or unknown proteins such as mitogen-activated protein kinase, maturation-promoting factor, endogenous meiosis inhibitor, Separase / Securin protein, and Aurora kinase can be activated by ubiquitin-proteasome pathway, phosphatidylinositol pathway , Receptor tyrosine kinase-Ras protein pathway, cAMP pathway and many other signaling pathways regulate oocyte maturation. It is helpful to further explore the regulatory mechanism of oocyte maturation by studying the key protein interactions in these pathways.