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目的:观察放化疗配合不同组分的中药复方治疗鼻咽癌的中长期疗效。方法:145例中药联合放化疗综合治疗实验组和140例放化疗综合治疗对照组,放疗方案均在第一阶段采用面颈联合野加下颈切线野照射,鼻咽部剂量达36~40Gy,再采用面颈分野连续照射,同步化疗采用DF方案化疗,实验组同时分别在放化疗前、放化疗中和放化疗后的治疗全程加服不同组分的中药复方,每天频频温服。观察比较2组的近期疗效和远期生存率。结果:实验组和对照组患者3年生存率并无统计学差异,但实验组患者放化疗期间急性放射性反应、血液系统毒副作用明显较对照组减轻。结论:在整个鼻咽癌放化疗过程中,辅以不同组分的中药复方确可明显提高临床疗效和患者生存质量。
Objective: To observe the long-term effects of radiotherapy and chemotherapy combined with different components of traditional Chinese medicine on nasopharyngeal carcinoma. Methods: One hundred and forty-five cases of combined traditional Chinese medicine and radiotherapy and chemotherapy combined with chemotherapy and 140 cases of radiotherapy and chemotherapy combined with radiotherapy were used in the first phase. The dose of nasopharyngeal was 36-40 Gy, Then continuous irradiation with facial and neck field, simultaneous chemotherapy with DF chemotherapy, the experimental group at the same time, respectively, before and after radiotherapy and chemotherapy, radiotherapy and chemotherapy and radiotherapy and chemotherapy after treatment plus full dose of different components of traditional Chinese medicine compound, daily frequent warm clothes. Two groups were observed and compared the short-term efficacy and long-term survival rate. Results: There was no significant difference in the 3-year survival rate between the experimental group and the control group. However, acute radioactive reaction and hematological toxicity in the experimental group were significantly lower than those in the control group during radiotherapy and chemotherapy. Conclusion: During the whole course of radiotherapy and chemotherapy of nasopharyngeal carcinoma, the traditional Chinese medicine compound with different components can obviously improve the clinical curative effect and quality of life of the patients.