金黄色葡萄球菌的耐药性日趋严重,研发抑制细菌产生多药耐药现象的方法迫在眉睫。主动外排系统是导致细菌产生耐药性的主要原因,细菌外排泵能将体内不相关细胞的抗菌化合物排出体外,导致细菌耐药性升高。现就金黄色葡萄球菌主要的外排泵NorA抑制剂方面的研究进展进行综述,为临床治疗金黄色葡萄球菌感染提供新策略。 Staphylococcus aureus more and more drug resistance, the development of methods to inhibit bacterial multidrug resistance phenomenon is imminent. Active efflux system is the main reason leading to bacterial resistance. Bacterial efflux pump can excrete anti-bacterial compounds of unrelated cells in the body, resulting in increased bacterial resistance. The progress of research on NorA inhibitors, the main efflux pump of Staphylococcus aureus, is reviewed. It provides a new strategy for the clinical treatment of Staphylococcus aureus infection.