DNA疫苗出现于20世纪90年代,Wolff首先发现携带外源基因的质粒DNA通过肌内注射可以使外源基因在体内表达,这激起了科学家们对DNA疫苗最初的探索,随后Tang等进行了人类历史上首次DNA疫苗实验,由此一个新型疫苗形式诞生了[1-2]。 DNA vaccines appeared in the 1990s. Wolff first discovered that exogenous genes can be expressed in vivo by intramuscular injection of a plasmid DNA carrying a foreign gene, which has aroused scientists’ initial exploration of the DNA vaccine. Tang et al. The first DNA vaccine experiment in human history led to the birth of a new form of vaccine [1-2].