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目的分析比较国产与进口维库溴铵的临床药效。方法选取云南省西双版纳州人民医院2014年3月至2015年3月进行全身麻醉手术治疗的120例患者为研究对象,按随机数字表法分为两组,观察组患者采用进口维库溴铵,对照组患者采用国产维库溴铵,比较分析两组患者的临床药效。结果两组患者注射维库溴铵后,观察组患者的起效时间和阻滞程度与对照组基本相同,两组患者注射药物前后,收缩压、舒张压及心率均无明显变化,差异均无统计学意义(均P>0.05)。观察组患者的药物作用时间和恢复时间明显高于对照组,并且观察组患者插管条件达到优(1级)者56例(93.3%),良(2级)4例(6.7%),明显优于对照组患者[插管条件达到优(1级)者47例(78.3%),良(2级)12例(20.0%),差(3级)1例(1.7%)],差异有统计学意义(P<0.05)。结论国产与进口维库溴铵的临床药效相似,但是在使用时需要根据患者的手术时间合理选择药物。
Objective To analyze and compare the clinical efficacy of domestic and imported vecuronium. Methods A total of 120 patients undergoing general anesthesia surgery in People’s Hospital of Xishuangbanna Prefecture in Yunnan Province from March 2014 to March 2015 were divided into two groups according to random number table. The patients in the observation group were treated with vecuronium, The control group of patients with domestic vecuronium bromide, a comparative analysis of two groups of patients clinical efficacy. Results After the two groups of patients received vecuronium, the observation group of patients with onset time and extent of arrest was basically the same as the control group, before and after injection of two groups of patients with systolic blood pressure, diastolic blood pressure and heart rate had no significant change, Statistical significance (all P> 0.05). In the observation group, the duration of medication and the recovery time were significantly higher than those in the control group, and 56 cases (93.3%) had excellent intubation conditions (grade 1) and 4 cases (6.7%) in the good (grade 2) 47 cases (78.3%) had excellent intubation conditions (grade 1), 12 cases (20.0%) had good (level 2), and 1 case (1.7%) had poor (grade 3)] in the control group Statistical significance (P <0.05). Conclusion The clinical efficacy of domestic and imported vecuronium is similar, but the drug should be selected reasonably according to the patient’s operation time.