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目的:探讨TLR4在前列腺癌(PCa)中的表达情况及意义。方法:采用免疫组化法检测TLR4与Survivin蛋白在41例PCa及20例良性前列腺增生(BPH)组织中的表达,同时分析TLR4和Survivin蛋白表达与Gleason系统分级的关系。结果:TLR4与Survivin蛋白在BPH组织中的阳性表达例数分别为15例(75%)与0例(0),在PCa组织中的阳性表达例数分别为18例(43.9%)与28例(68.3%),TLR4表达与PCa的Gleason系统分级有显著相关性(P<0.05),随着Gleason评分增高,TLR4表达降低。Survivin蛋白的表达与Gleason系统分级无关(P>0.05)。结论:TLR4表达与PCa Gleason系统分级相关,其表达与PCa的发生发展密切相关,可成为估计肿瘤预后的一项指标。
Objective: To investigate the expression and significance of TLR4 in prostate cancer (PCa). Methods: The expressions of TLR4 and Survivin protein in 41 cases of PCa and 20 cases of benign prostatic hyperplasia (BPH) were detected by immunohistochemistry. Meanwhile, the relationship between TLR4 and Survivin protein expression and Gleason system grade was analyzed. Results: The positive expression rates of TLR4 and Survivin in BPH tissues were 15 (75%) and 0 (0), respectively. The positive expression rates of TLR4 and Survivin in BPH were 18 (43.9%) and 28 (68.3%). There was a significant correlation between TLR4 expression and Gleason system grade in PCa (P <0.05). The TLR4 expression decreased with the increase of Gleason score. The expression of Survivin protein was not related to the Gleason system (P> 0.05). CONCLUSION: The expression of TLR4 is related to the grading of PCa Gleason system. The expression of TLR4 is closely related to the occurrence and development of PCa, which may be an index to evaluate the prognosis of the tumor.