目的:研究在2型糖尿病患者中发生周围神经病变与血清25羟维生素D_3水平之间的关系。方法:选取我院自2015年4月~2016年4月期间诊治的40例合并周围神经病变的2型糖尿病患者作为实验组,选取同期收治的单纯2型糖尿病患者作为参照组,对比分析两组患者血清25羟维生素D_3水平、实验室检测指标水平,研究2型糖尿病周围神经病变以及血清25羟维生素D_3的关系。结果:实验组与参照组2型糖尿病患者在PTH、血肌酐、血磷、血钙等指标方面差异并不显著,统计学不存在意义。经Pearson检验,血清25羟维生素D_3与患者年龄、体重指数、吸烟史等之间不存在相关性,与糖尿病病程成负相关。实验组患者血清25羟维生素D_3水平对比参照组存在统计学有意义,2型糖尿病周围神经病变与血清25羟维生素D_3在体内的含量有关。结论:2型糖尿病周围神经病变以及血清25羟维生素D_3之间存在负相关性。 AIM: To investigate the relationship between peripheral neuropathy and serum 25-hydroxyvitamin D3 levels in type 2 diabetic patients. Methods: Forty patients with type 2 diabetes mellitus complicated with peripheral neuropathy diagnosed and treated in our hospital from April 2015 to April 2016 were selected as the experimental group, patients with type 2 diabetes mellitus treated at the same period were selected as the reference group, and two groups were compared Serum 25 Hydroxyvitamin D 3 levels, laboratory test indicators, study of type 2 diabetic peripheral neuropathy and serum 25 hydroxyvitamin D 3 relationship. Results: There was no significant difference in PTH, serum creatinine, serum phosphorus and serum calcium between experimental group and reference group in type 2 diabetes mellitus, and there was no statistical significance. Pearson test, serum 25 hydroxyvitamin D3 and patient age, body mass index, smoking history, etc. There is no correlation between diabetes and the course of a negative correlation. Serum 25-hydroxyvitamin D 3 levels in the experimental group were statistically significant compared with the reference group. Peripheral neuropathy of type 2 diabetes was related to the content of 25-hydroxyvitamin D 3 in the body. Conclusion: There is a negative correlation between peripheral neuropathy in type 2 diabetes and serum 25-hydroxyvitamin D3.