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目的 分析细胞周期素依赖激酶 4(CDK4)在颌骨软骨肉瘤的表达及意义 .方法 利用免疫组化法检测 CDK4在2 0例颌骨软骨肉瘤、8例骨软骨瘤和 8例骨质增生中的表达 .结果 6 5 .0 % (13/ 2 0 )的软骨肉瘤中 CDK4呈阳性表达 ,CDK4表达率随病理学分级的升高呈增高趋势 ,但未见统计学差异 (P>0 .0 5 ) ;CDK4在骨软骨瘤和骨质增生中的阳性表达率分别为 12 .5 % (1/ 8)和 0 (0 / 8) ,且均与软骨肉瘤有显著性差异 (P<0 .0 5 ) .结论 CDK4在颌骨软骨肉瘤中过表达并与其发生发展相关 .
Objective To analyze the expression and significance of cyclin dependent kinase 4 (CDK4) in chondrosarcoma of the jaw.Methods CDK4 was detected by immunohistochemistry in 20 cases of chondrosarcoma, 8 cases of osteochondroma and 8 cases of osteoarthritis .Results CDK4 was positively expressed in 65.0% (13/20) chondrosarcoma, while the expression of CDK4 increased with the increase of pathological grade, but no statistical difference was found (P> 0.05) 5). The positive rates of CDK4 in osteochondroma and osteoarthritis were 12.5% (1/8) and 0 (0/8), respectively, which were significantly different from those in chondrosarcoma (P <0. 0 5) .Conclusion CDK4 is overexpressed in the chondrosarcoma of the jaw and related to its development.