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自然杀伤性 T 细胞(NKT 细胞)是一种同时具有自然杀伤细胞(NK 细胞)和 T 细胞部分表型及功能的细胞亚群。它们能将固有免疫应答和适应性免疫应答连接起来,识别 CD1d-糖脂抗原,分泌细胞因子,参与调节机体的免疫应答。由于机体一些器官中(如肝脏)富含 NKT 细胞,因此 NKT 细胞在肝脏中的作用引起了人们的广泛兴趣。NKT 细胞参与机体对乙型肝炎病毒的免疫应答,它们一方面抑制病毒复制,另一方面引起肝脏的免疫损伤,因而研究 NKT 细胞及其在乙型病毒性肝炎治疗中的作用可以对乙型病毒性肝炎的治疗提供新的思路。
Natural killer T cells (NKT cells) are a subset of cells that have both the natural killer (NK) and T cell phenotypes and functions. They link innate and adaptive immune responses, recognize CD1d-glycolipid antigens, secrete cytokines and are involved in the regulation of the body’s immune response. As some organs in the body (such as the liver) are rich in NKT cells, the role of NKT cells in the liver has aroused widespread interest. NKT cells involved in the body’s immune response to hepatitis B virus, they inhibit viral replication on the one hand, and cause immune damage to the liver on the other hand, thus studying NKT cells and their role in the treatment of hepatitis B can be hepatitis B virus Hepatitis treatment provides new ideas.