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本研究检验在盐敏感性高血压时,肾脏组织中T淋巴细胞浸润的作用和机制。在达尔(Dahl)盐敏感性(salt-sensitive,SS)大鼠模型中,当饮食中NaCl浓度从0.4%提高到4.0%时,其肾脏组织中浸润的T淋巴细胞数目明显增加,从(7.2±1.8)×105个细胞/2侧肾脏升至(18.2±3.9)×105个细胞/2侧肾脏(n=6/组)。此外,在以4.0%NaCl喂养的大鼠肾脏的T细胞中,免疫反应性烟酰胺腺嘌
This study examined the role and mechanism of T lymphocyte infiltration in renal tissues during salt-sensitive hypertension. In the Dahl salt-sensitive (SS) rat model, the number of infiltrating T lymphocytes in the kidney tissue increased significantly as the dietary NaCl concentration increased from 0.4% to 4.0% ± 1.8) × 105 cells / 2 kidney to (18.2 ± 3.9) × 105 cells / 2 kidney (n = 6 / group). In addition, in T cells from rat kidneys fed with 4.0% NaCI, immunoreactive nicotinamide adenine