胰腺癌恶性程度很高,早期特异性诊断和治疗成为延长患者生存期的关键。survivin是凋亡抑制蛋白家族中最强的凋亡抑制因子,许多常见肿瘤都有其特异性表达,已成为肿瘤诊断和治疗研究的热点。现就survivin在胰腺癌中的表达、与胰腺癌的预后、胰腺癌的survivin靶向治疗等研究进展作一综述,并探讨胰腺癌靶向survivin分子影像诊断的可行性。 Pancreatic cancer is highly malignant, early diagnosis and treatment of specific patients to become prolonged survival of the key. Survivin is the strongest inhibitor of apoptosis in the family of apoptosis proteins. Many common tumors have their specific expression. Survivin has become a hot spot in the diagnosis and treatment of tumors. The expression of survivin in pancreatic cancer, the prognosis of pancreatic cancer and the targeted therapy of pancreatic cancer were reviewed. The feasibility of molecular imaging for the diagnosis of pancreatic cancer targeting survivin was explored.