目的探讨CT引导下经皮肺穿刺活检(PTNB)对肺部毛玻璃样病变(GGO)的诊断价值。方法回顾性分析2009年1月至2015年1月在川北医学院附属医院肺部GGO行CT引导下PTNB的患者资料。根据病变大小(≤10 mm,10~20 mm,≥20 mm)、针道距离(≤5 cm,5~9 cm,≥9 cm)及GGO成分的比例(50%~90%,>90%)对患者进行分组。计算CT引导下PTNB对GGO总的及各组的敏感性、特异性及准确性,并采用Fisher’s确切概率法比较各组间的差异。统计分析采用SPSS 17.0软件。结果共纳入60例患者,包括恶性病变48例,良性病变12例。CT引导下PTNB对肺部GGO的敏感性、特异性、准确性分别为87.5%、100%、90%。对于不同大小、针道距离及GGO比例的病变,诊断价值差异均无统计学意义(P均>0.05)。结论对于肺部GGO的诊断,CT引导下PTNB具有较高的诊断价值,可作为其重要的诊断方法之一。 Objective To investigate the diagnostic value of CT guided percutaneous lung biopsy (PTNB) in the diagnosis of pulmonary frosted glassy lesions (GGO). Methods We retrospectively analyzed the data of patients undergoing PTNB guided by CT in the lungs of GGO department of North Sichuan Medical College Affiliated Hospital from January 2009 to January 2015. According to the lesion size (≤10 mm, 10-20 mm, ≥20 mm), the distance of the needle track (≤5 cm, 5-9 cm, ≥9 cm) and the proportion of GGO components (50% -90%,> 90% Patients were grouped. The sensitivity, specificity and accuracy of CT-guided PTGAs for GGO in all groups were calculated. Fisher’s exact test was used to compare the differences between groups. Statistical analysis using SPSS 17.0 software. Results A total of 60 patients were included, including 48 cases of malignant lesions and 12 cases of benign lesions. The sensitivity, specificity and accuracy of CT-guided PTNB on lung GGO were 87.5%, 100% and 90%, respectively. There was no significant difference in the diagnostic value of lesions of different size, distance between the needle track and GGO (all P> 0.05). Conclusion For the diagnosis of lung GGO, PTNB has a high diagnostic value under the guidance of CT, which can be used as one of the important diagnostic methods.