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[目的]3-[α-甲氧基亚氨基-α-(2-羟基苯基)-甲基]-5,6-二氢-1,4,2-二噁嗪是甲氧基丙烯酸酯类杀菌剂的一个重要中间体。[方法]以邻羟基苯乙酸甲酯为原料,经羟基保护、肟化、甲基化、环合、脱保护合成3-[α-甲氧基亚氨基-α-(2-羟基苯基)-甲基]-5,6-二氢-1,4,2-二噁嗪。[结果]在优化的反应条件下,反应总收率为27.0%(以邻羟基苯乙酸甲酯计),含量为98.5%,其结构经1H NMR和红外分析确认。[结论]该工艺简单经济,条件温和,适合工业化生产。
[Objective] 3- [α-Methoxyimino-α- (2-hydroxyphenyl) -methyl] -5,6- dihydro-1,4,2-dioxazine is a methoxyacrylate An important intermediate for fungicides. [Method] Methyl [- methoxyimino -? - (2-hydroxyphenyl) methyl] -methyl] -5,6-dihydro-1,4,2-dioxazine. [Result] Under the optimized reaction conditions, the total yield of the reaction was 27.0% (based on methyl o-hydroxy phenyl acetate), the content was 98.5%. Its structure was confirmed by 1H NMR and IR. [Conclusion] The process is simple and economical, mild conditions, suitable for industrial production.