在蚊子群体中实施基因驱动以控制疟疾通常有3种方法:(1)传播有害突变以减少蚊子数目;(2)使群体的性别比失衡;(3)修饰蚊子自身基因,使其对疟疾寄生虫产生抗体。(1)种群范围内的基因敲除有些基因对于蚊子的存活或繁殖是必需,基因驱动可以破坏它们。在这种情况下,研究人员在蚊子生殖细胞中限制必需基因的表达,而向体细胞中插入遗传元件(也称为基因驱动)的一个拷贝,同时仍然携带蚊子基因的一个功能性拷 There are usually three ways to implement gene-driven malaria control in mosquito populations: (1) spreading harmful mutations to reduce the number of mosquitos; (2) imbalanced the sex ratio of the population; (3) modifying the mosquito’s own genes to parasitize malaria Insect produces antibodies. (1) Population-wide knockout Some genes are essential for the survival or reproduction of mosquitoes and gene-driven destruction of them. In this case, researchers limited the expression of essential genes in mosquito germ cells, inserting a copy of the genetic element (also called gene-driven) into somatic cells while still carrying a functional copy of the mosquito’s gene