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目的探讨川芎嗪与丁咯地尔治疗急性脑栓塞的临床疗效及其对血液流变学的影响。方法将我院自2009年2月至2011年2月收治的62例急性脑栓塞患者随机分为对照组和治疗组,每组31例。两组均给予急性脑栓塞的常规治疗方法,对照组在常规治疗基础上给予川芎嗪注射液治疗,治疗组给予丁咯地尔注射液治疗。观察两组患者的临床疗效、血液流变学指标。结果治疗组的显效率和总有效率均明显高于对照组(P<0.01或P<0.05);两组患者治疗后的血液流变学参数均比治疗前有所改善,且治疗组患者各项血液流变学参数的改善均优于对照组(P<0.05)。结论丁咯地尔治疗急性脑栓塞比川芎嗪的疗效更佳,且无严重的毒副反应,适宜临床广泛应用。
Objective To investigate the clinical efficacy of ligustrazine and buflomedil in the treatment of acute cerebral embolism and its effect on hemorrheology. Methods Sixty-two patients with acute cerebral embolism who were admitted to our hospital from February 2009 to February 2011 were randomly divided into control group and treatment group, with 31 cases in each group. The two groups were given routine treatment of acute cerebral embolism, the control group on the basis of conventional therapy was given ligustrazine injection, the treatment group was given buflomedil injection. The clinical curative effect and hemorheology index of two groups were observed. Results The effective rate and total effective rate in the treatment group were significantly higher than those in the control group (P <0.01 or P <0.05). The hemorheological parameters in both groups were improved after treatment, and the patients in the treatment group The improvement of hemorrheological parameters were better than the control group (P <0.05). Conclusion Buflomedil is more effective than ligustrazine in the treatment of acute cerebral embolism. It has no serious side effects and is suitable for clinical application.