患者　女 ,2 7岁 ,结婚 5年。怀孕 9次 ,均于孕 4 0～ 5 0天自然流产。患者表型正常 ,智力良好。多次妇产科全面检查 ,未发现早期流产的原因。患者母亲无流产史 ,一兄一妹结婚后均正常生育。夫妇外周血淋巴细胞染色体检查 ,丈夫核型正常 ,妻子核型为 4 6 ,XX,t(3;11;14 ) der(3 Female patient, 27 years old, married for 5 years. Pregnancy 9 times, all in pregnancy 40 ~ 50 days of spontaneous abortion. Patients with normal phenotype, good intelligence. Multiple obstetrics and gynecology a comprehensive examination, did not find the cause of early abortion. No history of abortion in patients with mothers, one brother and one sister are married after normal fertility. Chromosome examination of peripheral blood lymphocytes in couples showed that the karyotype of her husband was normal and his wife’s karyotype was dermal (3; 11; 14) der (3