目的　为做好急性弛缓性麻痹 (AFP)病例监测 ,巩固无脊髓灰质炎 (脊灰 )成果。方法　对贵州省 1 999～2 0 0 2年 40 3例残留麻痹的AFP病例的流行病学特征、免疫状况和疾病谱进行了分析。结果　 64 3%的病例为 <5岁儿童 ,6～ 8月发病较多 ,未服苗和服苗 <3次的占 34 0 %。引起残留麻痹的疾病 ,格林 巴利综合征占 52 1 % ,6 2 %的病例为临床符合脊灰和诊断不详病例 ,其中 7例怀疑为接触者疫苗相关麻痹型脊灰。结论　为维持无脊灰状态 ,应加强AFP病例监测 ,提高合格粪便标本的采集率和口服脊灰疫苗常规免疫覆盖率 The aim is to monitor acute flaccid paralysis (AFP) cases and consolidate poliomyelitis-free (polio) outcomes. Methods The epidemiological characteristics, immune status and disease spectrum of 40 3 AFP cases with residual paralysis in Guizhou Province from 1999 to 2002 were analyzed. Results Sixty-three percent of cases were children <5 years of age with more morbidity from June to August than 34% of those who had not taken the vaccine. 52.1% were caused by Guillain-Barre syndrome and 62.2% were clinically polio-incompetent and diagnosed. Seven of them were suspected to be vaccine-associated paralytic polio. Conclusion In order to maintain the status of polio-free status, monitoring of AFP cases should be strengthened to improve the collection rate of qualified stool specimens and the routine immunization coverage of oral polio vaccine