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目的 研究胰岛素样生长因子Ⅰ (IGF -Ⅰ )及其结合蛋白 -3(IGFBP -3)与肝硬化患者肝功能的关系 ,评估胰岛素样生长因子I及其结合蛋白 -3测定对肝硬化患者的临床意义。方法 肝硬化患者 6 5例 ,按Child -pugh分级法将其分为A(17例 ) ,B(2 0例 )和C(2 8例 )三组 ;对照组 30例。应用放射免疫法检测空腹IGF -I和IGFBP -3水平 ,同时测定肝功能。结果 肝硬化患者血清中的IGF -I和IGFBP -3水平明显低于对照组 [(10 0 .49± 38.11)ng/mlvs(35 2 .5 5±15 3 6 1)ng/ml,P <0 .0 0 1;(45 .0 2± 16 .2 1)nmol/Lvs (114 .5 0± 2 7.0 9)nmol/L ,P <0 .0 0 1] ,且按Child -pugh分级的A ,B ,C组间的IGF -I和IGFBP -3水平差异具有显著性 (P <0 .0 0 1) ,呈递减趋势 ,与部分肝功能指标呈明显相关 (P <0 .0 1)。结论 IGF -I和IGFBP -3可作为反映肝硬化患者肝细胞活性的间接指标
Objective To investigate the relationship between insulin-like growth factor-1 (IGF-Ⅰ) and its binding protein-3 (IGFBP-3) and liver function in patients with liver cirrhosis and evaluate the relationship between insulin-like growth factor I and its binding protein- Clinical significance. Methods Sixty-five patients with cirrhosis were divided into three groups according to Child-Pugh classification: A (17 cases), B (20 cases) and C (28 cases). The control group included 30 cases. Fasting IGF-I and IGFBP-3 levels were measured by radioimmunoassay, and liver function was also measured. Results Serum levels of IGF-I and IGFBP-3 in patients with cirrhosis were significantly lower than those in the control group [(100.49 ± 38.11) ng / ml vs (35.25 ± 153.61) ng / ml, P < (45.0 ± 16.21) nmol / Lvs (114.50 ± 2 7.09) nmol / L, P <0.001), and were classified according to Child-pugh score The differences of IGF-I and IGFBP-3 levels between A, B and C groups were significant (P <0.01), showing a decreasing trend and were significantly correlated with some liver function indexes (P <0.01) . Conclusion IGF-I and IGFBP-3 can be used as indirect indicators of liver cell activity in patients with cirrhosis