马凡综合征是一种全身结缔组织先天性障碍疾病 ,系常染色体显性遗传。我们发现一家系 3例报告如下。1　病例报告先证者女 36岁 (家系图 3) ,因反复胸痛胸闷 3年 ,加重10 d就诊。体型瘦长 ,身高 170 cm ,蜘蛛指 (趾 ) ,拇指征阳性 ,腕征阳性 ,双眼近视 ,视力 OD 4.2 ,OS 4.0 ,B Marfan syndrome is a systemic connective tissue congenital disorders, Department of autosomal dominant. We found a family of 3 cases reported as follows. A case report The proband was 36 years old (family Figure 3), chest pain due to repeated chest pain for 3 years, increased 10 d treatment. Slim, 170 cm tall, Spider’s finger, Positive thumb, Positive wrist, Myopic eyes, Eyesight OD 4.2, OS 4.0, B